High resolution

Module 1: Figure chemokines

Summary of the four chemokine families and their G protein-coupled receptors.

The four chemokine families CXC (α), CC (β), C (γ) and CX3C (δ) are subdivided on the basis of conserved cysteine residues located in the N-terminal region (see the models for each family). For example, the ligands for the CXC family (CXCL) have two cysteine residues separated by a single amino acid (X). There are seven receptors CXCR1–7 for the CXCLs. A similar terminology applies to the other families. The CX3C (δ) family is unusual in that it has a single member CX3CL1 that is tethered to membranes through its C-terminal region. It can act on its CX3CR1 either in this tethered form or after it has been released from the membrane by proteases. This Figure is based on information contained in Box 1 from Rostène et al. (2007).