High resolution

Module 1: Figure MMP activation and function

Activation and function of the matrix metalloproteinases (MMPs).

The matrix metalloproteinases (MMPs) are activated either by certain soluble MMPs or by one of the membrane-type MMPs (shown in green), which cleave off the prodomain (Pro). The activated MMPs degrade components of the extracellular matrix (ECM). This hydrolytic activity is inhibited by soluble tissue inhibitors of metalloproteinases (TIMPs) or by the membrane-bound reversion-inducing cysteine-rich protein with Kazal motifs (RECK).