High resolution

Module 1: Figure Eph receptor signalling

Signal transduction by the Eph receptor/ephrin system.

Activation of the Eph receptors depends upon their dimerization following their binding to the ephrin ligands. The ephrin-A ligands are attached to PtdIns in the membrane through a glycosylphosphatidylinositol (GPI) anchor. The ephrin-B ligands are transmembrane proteins that have a cytoplasmic domain capable of reverse signalling. For forward signalling by the Eph receptors, transphosphorylation by the kinase domains of tyrosine residues provide binding sites for various transducing elements, of which many function to control actin remodelling.