High resolution

Module 1: Figure EGF stimuli and receptors

Epidermal growth factor (EGF) family of stimuli and their receptors.

Epidermal growth factor (EGF) stimuli precursors are located in the plasma membrane and are then cleaved by proteases, such as the ADAM proteases. The soluble growth factors then act on two of the main EGF receptor types. AR, amphiregulin; BTC, betacellulin; EPR, epiregulin; HB-EGF, heparin-binding EGF-like growth factor; TGFα, transforming growth factor-α.