Please cite as Berridge, M.J. (2011) Cell Signalling Biology; doi:10.1042/csb0001001
Activation of the non-receptor tyrosine kinase Src.
Module 1: Figure Src activation (animated)
Src is the prototype of the family of Src tyrosine kinases that have a similar activation mechanism. 1. A C-terminal phosphotyrosine group is removed to open up the molecule. 2. Tyrosine kinases phosphorylate a residue within the kinase domain resulting in an increase in enzyme activity. 3. The activated kinase domain can phosphorylate various target proteins such as Abl. 4. The SH2 and SH3 domains can bind various target proteins. 5. C-terminal Src kinase (CSK) phosphorylates the C-terminal tyrosine residue to reinstate the inactive conformation.