Please cite as Berridge, M.J. (2011) Cell Signalling Biology; doi:10.1042/csb0001001
Activation of the platelet-derived growth factor receptor (PDGFR).
Module 1: Figure PDGFR activation (animated)
The PDGFR is a typical protein tyrosine kinase-linked receptor. The PDGF dimer binds together two PDGFR monomers, which then phosphorylate each other on multiple tyrosine residues that then provide docking sites for components of a number of prominent signalling pathways.