High resolution

Module 1: Figure receptor down-regulation



Cbl-dependent down-regulation of protein tyrosine kinase-linked receptors (PTKRs).

The down-regulation of protein tyrosine kinase-linked receptors (PTKRs), such as the epidermal growth factor receptor (EGFR)and the Met receptor, is regulated by the adaptor protein Cbl, which binds to the activated receptor and initiates its degradation through a ubiquitination process that proceeds through Steps 1–8 as described in the text.