High resolution

Module 1: Figure PDGFR activation



Activation of the platelet-derived growth factor receptor (PDGFR).

The PDGFR is a typical protein tyrosine kinase-linked receptor. The PDGF dimer binds together two PDGFR monomers, which then phosphorylate each other on multiple tyrosine residues that then provide docking sites for components of a number of prominent signalling pathways. An animated version of this Figure is available.